Description

6-Valine-Tyrocidine A is a defined analog of the tyrocidine antibiotic complex, a family of cyclic decapeptides. This specific derivative is valued for its role in advanced biochemical research and as a critical reference standard for studying antimicrobial peptides and their structure-activity relationships. It is primarily utilized by researchers in pharmaceutical development, microbiology, and peptide chemistry for investigating novel therapeutic agents and resistance mechanisms.

Application

• Biochemical Research: Serves as a key reference compound for studying the mechanism of action, structure, and biological activity of tyrocidine antibiotics.
• Antimicrobial Studies: Used as a standard in assays to evaluate the efficacy and spectrum of new antimicrobial peptides against Gram-positive bacteria.
• Pharmaceutical Development: Acts as a building block or model compound in the research and development of novel peptide-based therapeutics.
• Analytical Standard: Employed as a high-purity calibrant in analytical methods such as HPLC and mass spectrometry for quality control and method validation.
• Microbiology Research: Utilized in studies focusing on bacterial cell membrane disruption and the development of bacterial resistance to peptide antibiotics.

Basic Information

Product Name	6-Valine-Tyrocidine A
CAS No.	79774-98-4
Molecular Formula	C66H88N14O12
Molecular Weight	1261.5 g/mol
Synonyms	Tyrocidine A, 6-L-Valine-; Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu); Tyrocidine A (6-Val); [Val6]-Tyrocidine A; Gramicidin S-related peptide; Antibiotic Tyrocidine A variant; Cyclic decapeptide antibiotic analog
EINECS	Contact for details

Quality Control

Our 6-Valine-Tyrocidine A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.