Description

3-Iodo-L-Tyrosine Methyl Ester Hydrochloride is a chemically modified derivative of the essential amino acid L-tyrosine, serving as a critical synthetic intermediate and research tool. This compound is valued for its iodine-labeled aromatic ring, which is instrumental in radiopharmaceutical development, peptide synthesis, and biochemical research. It is primarily required by pharmaceutical R&D laboratories, radiochemistry facilities, and academic institutions engaged in metabolic studies, tracer development, and advanced organic synthesis.

Application

• Radiopharmaceutical Precursor: Key intermediate in the synthesis of iodine-123 or iodine-131 labeled compounds for diagnostic imaging and therapeutic applications.
• Peptide Synthesis Building Block: Used in solid-phase and solution-phase peptide synthesis to incorporate iodotyrosine residues into peptide chains for structure-activity relationship (SAR) studies.
• Biochemical Research Reagent: Employed in enzyme inhibition studies, particularly for tyrosine kinase and thyroid hormone biosynthesis pathway research.
• Metabolic Tracer Development: Serves as a starting material for creating labeled tracers to study protein metabolism and thyroid hormone synthesis in vivo.
• Reference Standard: Used as a high-purity analytical standard in HPLC and LC-MS methods for quality control and metabolic profiling.
• Organic Synthesis Intermediate: A versatile synthon for further chemical modifications to create novel tyrosine analogs and specialized fine chemicals.

Basic Information

Product Name	3-Iodo-L-Tyrosine Methyl Ester Hydrochloride
CAS No.	79677-58-0
Molecular Formula	C10H13INO3 • HCl
Molecular Weight	373.58 g/mol
Synonyms	L-Tyrosine, 3-iodo-, methyl ester, hydrochloride; Methyl (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoate hydrochloride; 3-Iodo-L-tyrosine methyl ester HCl; 3-Iodo-O-methyl-L-tyrosine hydrochloride; (S)-Methyl 2-amino-3-(4-hydroxy-3-iodophenyl)propanoate hydrochloride; 3-Iodo-L-tyrosine O-methyl ester hydrochloride; Methyl 3-iodo-L-tyrosinate hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, providing detailed results for all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.