Description

Cyclic Leucine Enkephalin CAS NO 79525-56-7 is a synthetic, cyclic peptide analog of the endogenous opioid peptide leucine enkephalin, designed for enhanced metabolic stability and receptor selectivity. This compound is a critical research tool for investigating the opioid system, pain pathways, and neuropharmacology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on CNS drug discovery and neurobiological studies.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to explore δ-opioid receptor (DOR) activity and signaling.
• Pain Mechanism Studies: Serves as a key reference standard in preclinical research to understand the role of enkephalins in analgesia and pain modulation.
• Drug Discovery & Development: Acts as a lead compound or pharmacological tool for designing and screening novel analgesic agents with improved stability profiles.
• Biochemical Assays: Employed in enzyme inhibition studies, such as with neutral endopeptidase (NEP), to investigate peptide degradation pathways.
• Academic & Clinical Research: Supports fundamental research into opioid peptide biology, receptor interactions, and their implications in various neurological conditions.

Basic Information

Product Name	Cyclic Leucine Enkephalin
CAS No.	79525-56-7
Molecular Formula	C28H35N5O7
Molecular Weight	553.61 g/mol
Synonyms	Cyclo[Leu-enkephalin]; H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-Leu-OH (cyclic disulfide bridge); Cyclic Leu-Enkephalin; c-[Leu5]enkephalin; cLE; Cyclic (5→2')-Leucine Enkephalin; [D-Cys2,5]Leu-Enkephalin; Opioid peptide analog
EINECS	Contact for details

Quality Control

Our Cyclic Leucine Enkephalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For specific purity requirements (e.g., >95%, >98%), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.