Description

Dolastatin 1 is a potent cytotoxic linear peptide originally isolated from the marine sea hare Dolabella auricularia. This compound serves as a foundational lead structure in the development of novel anticancer agents and antibody-drug conjugates (ADCs), representing a significant class of tubulin polymerization inhibitors. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on oncology drug discovery and mechanism of action studies. The high biological activity of Dolastatin 1 makes it a critical reference standard and a valuable tool compound for biochemical research.

Application

• Anticancer Drug Discovery: Serves as a key lead compound and pharmacophore model for designing novel synthetic analogs with improved efficacy and reduced toxicity.
• Antibody-Drug Conjugate (ADC) Payload: Used as a reference standard in the development and quality control of ADCs, where its potent cytotoxic activity is leveraged for targeted cancer therapy.
• Biochemical Research: Employed as a specific inhibitor of tubulin polymerization to study microtubule dynamics, cell cycle progression, and mechanisms of mitosis.
• Pharmacology & Toxicology Studies: Utilized in in vitro and in vivo models to investigate potency, therapeutic index, and mechanism of action of new chemical entities.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control of related compounds in pharmaceutical manufacturing.
• Academic Research: Supports fundamental research in marine natural products, chemical biology, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Dolastatin 1
CAS No.	79394-15-3
Molecular Formula	C₆₀H₈₈N₁₀O₁₄
Molecular Weight	1173.4 g/mol
Synonyms	Dolastatin 1; DLS-1; (3S,6S,9S,12S,18S,21S,28S,31S)-31-[(2S)-2-Aminopentanamido]-12-[(2R)-2-hydroxy-2-methylpentanamido]-28-(hydroxymethyl)-3,6,9,21-tetramethyl-1,4,7,10,19,22,25,30-octaoxo-18-propyl-1,4,7,10,13,16,19,22,25,30-decazatritriacontane-29-carboxylic acid; Marine Peptide Dolastatin 1
EINECS	Contact for details

Quality Control

Our Dolastatin 1 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, MS, and NMR to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the assay purity and impurity profile. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize condensation and exposure to atmospheric moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.