Description

Acth (1-38), Phe(2)-Nle(4)-Iodo-Tyr(23)- CAS NO 79217-48-4 is a synthetic, iodinated analog of the adrenocorticotropic hormone (ACTH) fragment 1-38, designed for enhanced stability and specific receptor binding studies. This modified peptide is critical for advanced biochemical research and pharmaceutical development, offering a valuable tool for investigating the melanocortin system and related endocrine pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on endocrinology, metabolic disorders, and peptide-based therapeutic discovery.

Application

• Biochemical Research: As a key reagent for studying ACTH receptor (MC2R) binding affinity, signal transduction, and structure-activity relationships (SAR).
• Pharmaceutical Development: Used in the preclinical screening and development of novel therapeutics targeting adrenal function and metabolic syndromes.
• Diagnostic Assays: Serves as a reference standard or labeled tracer in immunoassays and radioreceptor assays for measuring ACTH levels.
• Endocrinology Studies: Facilitates research into the hypothalamic-pituitary-adrenal (HPA) axis, stress response, and corticosteroid synthesis regulation.
• Peptide Chemistry: An important compound for methodological studies in peptide modification, iodination techniques, and analog stability.

Basic Information

Product Name	Acth (1-38), Phe(2)-Nle(4)-Iodo-Tyr(23)- CAS NO 79217-48-4
CAS No.	79217-48-4
Molecular Formula	C207H310N56O58S2I
Molecular Weight	~4560.2 g/mol (monoisotopic)
Synonyms	ACTH (1-38), human, [Phe2, Nle4, Tyr(3-I)23]-; [Phe2, Nle4, 3-Iodo-Tyr23]-ACTH (1-38); Adrenocorticotropic Hormone (1-38) Iodinated Analog; [Iodo-Tyr23]-Corticotropin (1-38); Nle4, Phe2-ACTH (1-38) Iodo Derivative; 3-Iodo-L-tyrosyl23-corticotropin (1-38); Synthetic ACTH Fragment 1-38 Iodo Analog
EINECS	Contact for details

Quality Control

Our Acth (1-38), Phe(2)-Nle(4)-Iodo-Tyr(23)- is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous quality testing protocols, and specifications can be aligned with research-grade or cGMP standards upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.