Description

D-Ap5 is a potent and selective antagonist of the NMDA receptor, specifically targeting the glutamate binding site. This high-purity biochemical is critical for advanced neuroscience research and pharmaceutical development, enabling precise study of excitatory neurotransmission and neuroprotective pathways. It is essential for researchers and developers in neuropharmacology, neurodegenerative disease modeling, and the synthesis of novel central nervous system (CNS) targeting compounds.

Application

• Neuroscience Research: A key tool compound for studying NMDA receptor function, synaptic plasticity, and excitotoxicity in cellular and animal models.
• Neuropharmacology Development: Used as a reference standard and building block in the R&D of novel therapeutics for stroke, epilepsy, and chronic pain.
• Biochemical Assays: Serves as a selective antagonist in high-throughput screening (HTS) assays to identify new modulators of the NMDA receptor complex.
• Academic & Institutional Research: Fundamental for university and institutional labs investigating the mechanisms of learning, memory, and neurodegenerative diseases like Alzheimer's.

Basic Information

Product Name	D-Ap5
CAS No.	79055-68-8
Molecular Formula	C5H10N2O4
Molecular Weight	162.14 g/mol
Synonyms	D-2-Amino-5-phosphonopentanoic acid; (R)-2-Amino-5-phosphonopentanoic acid; D-AP5; D-APV; (R)-AP5; (R)-2-Amino-5-phosphonovaleric acid; NMDA receptor antagonist D-AP5; D-(-)-2-Amino-5-phosphonopentanoic acid
EINECS	Contact for details

Quality Control

Our D-Ap5 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support research and development with materials suitable for advanced applications, with purity levels typically exceeding 98% (HPLC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Biological Activity	NMDA receptor antagonism confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.