Description

4-(Trifluoromethyl)Phenyl Acetate is a versatile fluorinated aromatic ester, serving as a critical building block in advanced organic synthesis. Its value lies in the unique properties imparted by the trifluoromethyl group, which enhances lipophilicity, metabolic stability, and bioavailability in target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF₃ group improves pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies, enhancing thermal stability and optical properties.
• Polymer & Resin Modifier: Incorporated to create specialty polymers with improved chemical resistance, lower surface energy, and enhanced durability.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and as a protecting group in complex multi-step synthetic routes.
• Dye & Pigment Industry: Acts as an intermediate for synthesizing fluorinated dyes and pigments that offer superior lightfastness and color stability.

Basic Information

Product Name	4-(Trifluoromethyl)Phenyl Acetate
CAS No.	78950-29-5
Molecular Formula	C₉H₇F₃O₂
Molecular Weight	204.15 g/mol
Synonyms	p-(Trifluoromethyl)phenyl acetate; 4-Acetoxybenzotrifluoride; 1-[4-(Trifluoromethyl)phenyl] ethanone (common misnomer); α,α,α-Trifluoro-p-cresyl acetate; 4-Trifluoromethylphenol acetate; Acetic acid 4-(trifluoromethyl)phenyl ester; 4-(Trifluoromethyl)phenol acetate
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Phenyl Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.