Description

Dl-2-Amino-6-Phosphonohexanoic Acid CAS NO 78944-89-5 is a synthetic phosphonic acid derivative of the amino acid lysine, serving as a potent and selective antagonist for glutamate receptors. This compound is a critical research-grade biochemical for investigating excitatory neurotransmission and neuropharmacology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on neuroscience and drug discovery.

Application

• Neuroscience Research: As a selective NMDA (N-methyl-D-aspartate) receptor antagonist for studying excitatory synaptic transmission, neuronal plasticity, and neurotoxicity.
• Pharmacological Studies: Used in vitro and in vivo to model neurological conditions and evaluate potential neuroprotective agents.
• Biochemical Assay Development: A key reference standard and tool compound in high-throughput screening (HTS) assays targeting glutamate pathways.
• Academic & Institutional R&D: Fundamental research into the mechanisms of learning, memory, and neurodegenerative diseases.
• Preclinical Drug Discovery: Investigating lead compounds for stroke, epilepsy, chronic pain, and other CNS disorders.
• Specialty Chemical Synthesis: Serving as a sophisticated building block or intermediate for synthesizing more complex neuroactive molecules.

Basic Information

Product Name	Dl-2-Amino-6-Phosphonohexanoic Acid
CAS No.	78944-89-5
Molecular Formula	C6H14NO5P
Molecular Weight	211.15 g/mol
Synonyms	DL-AP6; DL-2-Amino-6-phosphonohexanoic acid; DL-2-Amino-6-phosphonocaproic acid; (±)-2-Amino-6-phosphonohexanoic acid; APV analogue; NMDA receptor antagonist AP6; 2-Amino-6-phosphonohexanoic acid (racemic); Phosphonoleucine derivative; (RS)-2-Amino-6-phosphonohexanoic acid
EINECS	Contact for details

Quality Control

Our Dl-2-Amino-6-Phosphonohexanoic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee it meets your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.