Description

Enkephalin, Ala(2)-Valnh2(5)- CAS NO 78873-50-4 is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified at the second and fifth amino acid positions. This compound is of significant value for research into the opioid receptor system, pain modulation, and neurological signaling pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and peptide-based drug discovery.

Application

• Neuroscience Research: Used as a selective tool compound for studying δ-opioid receptor (DOR) activity and function in vitro and in vivo.
• Pharmacological Assay Development: Serves as a reference standard or active control in high-throughput screening (HTS) assays for novel analgesic discovery.
• Biochemical Studies: Employed in binding affinity studies, signal transduction research, and structure-activity relationship (SAR) analysis of opioid peptides.
• Drug Discovery Pipeline: Acts as a key intermediate or lead compound in the development of new, non-addictive pain management therapeutics.
• Academic & Clinical Research: Supports fundamental investigations into the role of enkephalins in pain perception, mood regulation, and addiction mechanisms.

Basic Information

Product Name	Enkephalin, Ala(2)-Valnh2(5)-
CAS No.	78873-50-4
Molecular Formula	C28H44N8O8
Molecular Weight	620.70 g/mol
Synonyms	[D-Ala2]-Leu-Enkephalinamide; [D-Ala2]-Leu-Enkephalin amide; DADLE amide; H-Tyr-D-Ala-Gly-Phe-Leu-NH2; (5S)-5-[[(2S)-1-[[(2S)-1-[[(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-2-oxoethyl]amino]-3-phenyl-1-oxopropan-2-yl]amino]-5-oxopentan-1-aminium; D-Ala2, Leu5-Enkephalinamide; Tyr-D-Ala-Gly-Phe-Leu-NH2
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Enkephalin, Ala(2)-Valnh2(5)- undergoes rigorous purity verification and identity confirmation using advanced analytical techniques such as HPLC and mass spectrometry. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.