Description

Angiotensin I, Sar(1)-Ala(7)- is a synthetic peptide analog of the endogenous hormone Angiotensin I, specifically modified with sarcosine (Sar) at position 1 and alanine (Ala) at position 7. This modification makes it a valuable research-grade biochemical tool for studying the renin-angiotensin system (RAS), a critical pathway in cardiovascular and renal physiology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular drug discovery, enzyme inhibition studies, and receptor binding assays. The compound is supplied as a high-purity material to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to the renin-angiotensin-aldosterone system (RAAS).
• Drug Discovery & Development: Serves as a key reference standard and pharmacologically active compound in screening for novel cardiovascular therapeutics.
• Enzyme Kinetics: Employed to study the activity and inhibition of Angiotensin-Converting Enzyme (ACE) and other proteases in the RAS pathway.
• Receptor Binding Assays: Acts as a ligand in competitive binding studies to characterize Angiotensin receptor subtypes (AT1, AT2).
• Academic & Clinical Research: Supports fundamental investigations into hypertension, heart failure, and kidney disease mechanisms.
• Peptide Chemistry: Used as a building block or intermediate in the synthesis of more complex peptide analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Angiotensin I, Sar(1)-Ala(7)-
CAS No.	78809-84-4
Molecular Formula	C49H69N13O12
Molecular Weight	1032.2 g/mol
Synonyms	Saralasin Acetate; [Sar1, Ala8]-Angiotensin II; Sarcosine1, Alanine8-Angiotensin II; 1-Sar-8-Ala-angiotensin II; Sar1-Ala8-Ang II; Angiotensin II Antagonist; [Sar1,Ala8]Ang II; N-Sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-alanine
EINECS	Contact for details

Quality Control

Our Angiotensin I, Sar(1)-Ala(7)- is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, essential for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to GMP-like guidelines for research chemicals to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.