Description

1-(2-Hydroxy-Ethoxymethyl)-5-Iodo-1H-Pyrimidine-2,4-Dione is a halogenated pyrimidine derivative, a key intermediate in the synthesis of complex nucleoside analogs. This compound matters for its role in pharmaceutical research and development, particularly in the creation of antiviral and anticancer agents. It is needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on medicinal chemistry and nucleotide chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside-based antiviral drugs.
• Antiviral Agent Research: Used in the development and study of compounds targeting viral polymerases and reverse transcriptases.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Nucleoside Analog Synthesis: Key precursor for modifying the sugar and base moieties of nucleosides to alter their biological activity.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Labeled Compound Synthesis: The iodine atom provides a potential site for radiolabeling (e.g., with I-125) for tracer studies.

Basic Information

Product Name	1-(2-Hydroxy-Ethoxymethyl)-5-Iodo-1H-Pyrimidine-2,4-Dione
CAS No.	78692-74-7
Molecular Formula	C7H9IN2O5
Molecular Weight	328.06 g/mol
Synonyms	5-Iodo-1-(2-hydroxyethoxymethyl)uracil; 1-(2-Hydroxyethoxymethyl)-5-iodouracil; 5-Iodo-1-(2-hydroxyethoxymethyl)-2,4(1H,3H)-pyrimidinedione; 5-Iodo-HEMU; Iodinated HEMU; 5-Iodo-1-(β-hydroxyethoxymethyl)uracil
EINECS	Contact for details

Quality Control

Our 1-(2-Hydroxy-Ethoxymethyl)-5-Iodo-1H-Pyrimidine-2,4-Dione is produced under a strict quality management system. Products undergo rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.