Description

4-n-(4-Aminobenzenesulfonyl)Fortimicin B is a chemically modified derivative of the Fortimicin B aminoglycoside antibiotic, where a 4-aminobenzenesulfonyl group is introduced at the 4-nitrogen position. This structural modification is significant for creating novel semi-synthetic derivatives with potential for enhanced or altered biological activity, particularly in the research and development of new antimicrobial agents. It serves as a critical pharmaceutical intermediate and a valuable reference standard for scientists in pharmaceutical R&D, analytical laboratories, and academic institutions focused on antibiotic discovery and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel semi-synthetic aminoglycoside antibiotics for research purposes.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of related compounds.
• Antibiotic Research & Development: A crucial compound for studying structure-activity relationships (SAR) to develop new antimicrobial agents with improved efficacy or reduced toxicity.
• Biochemical Research: Employed in studies investigating the mechanism of action and resistance pathways of aminoglycoside antibiotics.
• Academic & Institutional Research: Used in university and institutional laboratories for chemical and pharmacological research projects.

Basic Information

Product Name	4-n-(4-Aminobenzenesulfonyl)Fortimicin B
CAS No.	78609-43-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fortimicin B, 4-N-(4-Aminobenzenesulfonyl) derivative; 4-Aminobenzenesulfonamido Fortimicin B; 4'-N-(4-Aminophenylsulfonyl)fortimicin B; 4-N-(4-Sulfoamidophenyl)fortimicin B; Antibiotic KA-6606 IX derivative; (4-Aminophenyl)sulfonylfortimicin B; 4-Epi-fortimicin B 4-N-(4-aminobenzenesulfonate)
EINECS	Contact for details

Quality Control

Our 4-n-(4-Aminobenzenesulfonyl)Fortimicin B is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and reference material applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.