Description

Fmoc-Lys(Fmoc)-OH is a critical, orthogonally protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its dual Fmoc-protected side chain provides a key building block for introducing lysine residues with a free carboxylic acid group, enabling precise control over peptide chain assembly. This high-purity intermediate is indispensable for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality reagents for constructing complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the Fmoc/t-Bu strategy, used to incorporate lysine residues into peptide sequences.
• Pharmaceutical Research & Development: Synthesis of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation and Linker Chemistry: Utilized to create functionalized peptides for attaching payloads, labels (e.g., fluorophores, biotin), or surfaces via its side-chain amine after deprotection.
• Combinatorial Library Synthesis: Key component in generating diverse peptide libraries for high-throughput screening in drug discovery.
• Material Science: Production of peptide-based biomaterials, hydrogels, and surface coatings.
• Antibody-Drug Conjugate (ADC) Development: Used in synthesizing peptide linkers that connect cytotoxic drugs to monoclonal antibodies.

Basic Information

Item	Detail
Product Name	Fmoc-Lys(Fmoc)-OH
CAS No.	78603-12-0
Molecular Formula	C36H34N2O6
Molecular Weight	590.67 g/mol
Synonyms	Nα,Nε-Bis(9-fluorenylmethoxycarbonyl)-L-lysine; Fmoc-Lys(Fmoc)-OH; Nα-Fmoc-Nε-Fmoc-L-lysine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid; Fmoc-Lys(Fmoc); Bis-Fmoc-L-lysine; Fmoc-Lys(Fmoc)-OH CAS 78603-12-0
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Lys(Fmoc)-OH is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the exacting standards required for advanced synthetic applications. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity (typically ≥98% by HPLC), and absence of critical impurities. Our quality commitment supports compliance in GMP and ISO-guided environments for research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); desiccate for long-term storage. Keep container tightly sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.