Description

Fmoc-o-Sulfo-L-Tyrosine Barium Salt Hydrate is a protected, sulfated derivative of the amino acid L-tyrosine, designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for the site-specific incorporation of tyrosine O-sulfation, a key post-translational modification, into synthetic peptides. It is an essential building block for researchers and manufacturers in pharmaceutical development, biochemical research, and proteomics who require high-purity, sequence-defined peptides with native modifications.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected, activated amino acid derivative for the automated synthesis of peptides containing sulfated tyrosine residues.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates targeting conditions where tyrosine sulfation plays a role, such as in hormone activity, receptor signaling, and inflammation.
• Biochemical Research: Production of modified peptides for studying enzyme kinetics, protein-protein interactions, and post-translational modification pathways.
• Proteomics & Antibody Development: Creation of antigens, standards, and tools for the detection and analysis of sulfated proteins and antibodies.
• Glycopeptide Mimetics: Used in the synthesis of complex biomimetics that combine sulfation with other modifications to mimic natural bioactive molecules.

Basic Information

Product Name	Fmoc-o-Sulfo-L-Tyrosine Barium Salt Hydrate
CAS No.	78553-20-5
Molecular Formula	C24H19BaNO10S • xH2O
Molecular Weight	Contact for details
Synonyms	Fmoc-Tyr(SO3H)-OH Barium Salt; Fmoc-O-sulfo-L-tyrosine barium salt hydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-sulfo-L-tyrosine barium salt; Fmoc-L-Tyrosine(OSO3H) Barium Salt; Barium Fmoc-O-sulfo-L-tyrosine hydrate; Fmoc-Tyr(SO3Ba)-OH; Fmoc-Tyr(SO3)-OH Barium Salt; Protected Sulfotyrosine Building Block
EINECS	Contact for details

Quality Control

Our Fmoc-o-Sulfo-L-Tyrosine Barium Salt Hydrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.