Description

Diethyl (4-Amino-3-Fluorophenyl)Methylmalonate is a high-purity fluorinated malonate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its bifunctional structure, incorporating both a reactive amino group and a fluorinated aromatic ring, which enables the construction of complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and pesticides that leverage fluorine's metabolic stability and bioavailability.
• Material Science Research: Used in the creation of specialty polymers and advanced organic materials where the fluorine atom imparts specific chemical resistance or electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing complex chelating ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable substrate for academic and industrial research into new fluorination methodologies and the study of structure-activity relationships (SAR).
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	Diethyl (4-Amino-3-Fluorophenyl)Methylmalonate
CAS No.	78543-08-5
Molecular Formula	C14H18FNO4
Molecular Weight	283.30 g/mol
Synonyms	Diethyl (4-Amino-3-fluorophenyl)methylpropanedioate; Propanedioic acid, 2-[(4-amino-3-fluorophenyl)methyl]-, 1,3-diethyl ester; 4-Amino-3-fluorobenzylmalonic acid diethyl ester; 1,3-Diethyl 2-[(4-amino-3-fluorophenyl)methyl]propanedioate; (4-Amino-3-fluorobenzyl)malonic Acid Diethyl Ester; Diethyl (4-Amino-3-Fluorobenzyl)malonate; 78543-08-5; 4-Amino-3-fluoro-α-(carbethoxy)benzeneacetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Diethyl (4-Amino-3-Fluorophenyl)Methylmalonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and production use. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.