Description

Copeptin (Human) is a stable glycopeptide fragment derived from the C-terminal region of the vasopressin prohormone. It serves as a reliable and sensitive surrogate biomarker for endogenous arginine vasopressin (AVP) release, which is crucial in the body's response to physiological stress. This makes it an invaluable tool for clinical diagnostics and biomedical research. Key industries that require this high-purity biochemical include in vitro diagnostic (IVD) kit manufacturers, pharmaceutical R&D laboratories, and academic institutions focused on cardiovascular, renal, and endocrine pathophysiology.

Application

• Clinical Diagnostics: Primary component in ELISA and other immunoassay kits for the quantitative measurement of copeptin in human serum or plasma, aiding in the diagnosis and risk stratification of heart failure, myocardial infarction, and sepsis.
• Biomarker Research: Used as a reference standard in studies investigating stress response, fluid balance disorders, and syndrome of inappropriate antidiuretic hormone secretion (SIADH).
• Assay Development & Validation: Serves as a critical calibrator and control material for the development and quality control of new diagnostic assays.
• Pharmaceutical Testing: Utilized in preclinical and clinical trials to monitor drug effects on the vasopressin system.

Basic Information

Product Name	Copeptin (Human)
CAS No.	78362-34-2
Molecular Formula	C106H165N31O33S
Molecular Weight	~2365.7 g/mol
Synonyms	C-terminal provasopressin; C-terminal proAVP (human); Preprovasopressin-neurophysin II-copeptin; AVP precursor fragment 126-164; Glycopeptide from vasopressin precursor; hCT-proAVP; Provasopressin C-terminal peptide; Arginine vasopressin precursor C-terminal peptide
EINECS	Contact for details

Quality Control

Our Copeptin (Human) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for diagnostic and research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity (by HPLC), peptide content, and biological activity. We support compliance with relevant IVD and GMP guidelines for critical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Biological Activity	Determined by immunoassay; consistent with stated activity
Endotoxin	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.