Description

α-n-Acetyl β-Endorphin (1-26) is a synthetic, acetylated fragment of the endogenous opioid peptide β-endorphin. This modification enhances its stability and resistance to enzymatic degradation, making it a valuable research-grade biochemical for studying opioid receptor interactions and neurobiological pathways. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and peptide-based therapeutic discovery.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of pain modulation, stress response, and reward mechanisms.
• Pharmacological Assays: Serves as a key ligand in receptor binding studies and functional assays to characterize opioid receptor subtypes (e.g., μ-opioid receptors).
• Biochemical Studies: Employed to investigate the structure-activity relationships (SAR) of endorphin peptides and the effects of N-terminal acetylation.
• Drug Discovery: Acts as a starting point or comparator in the development of novel analgesic or neuroprotective peptide therapeutics.
• Cell Signaling Research: Used to explore intracellular signaling cascades activated by opioid peptides in various cell culture models.

Basic Information

Product Name	α-n-Acetyl β-Endorphin (1-26)
CAS No.	78325-28-7
Molecular Formula	C140H220N34O42
Molecular Weight	3047.5 g/mol (approximate)
Synonyms	Acetyl-β-Endorphin (1-26); N-Acetyl-β-Endorphin (1-26); β-Endorphin (1-26), N-acetyl-; Ac-β-Endorphin(1-26); Acetylated β-Endorphin Fragment 1-26; Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu (N-acetyl); [Ac-Tyr1]-β-Endorphin (1-26); Opioid peptide fragment
EINECS	Contact for details

Quality Control

Our α-n-Acetyl β-Endorphin (1-26) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other key parameters. We adhere to rigorous internal quality standards to meet the exacting requirements of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Complies with theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.