Description

3-Bromo-4-Fluorobenzyl Bromide is a versatile and highly reactive bifunctional aromatic building block, essential for constructing complex molecular architectures. Its dual halogen functionality enables precise, sequential cross-coupling and substitution reactions, making it a critical intermediate for advanced chemical synthesis. This compound is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing benzyl-protected amines or aryl-fluorine motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the bromine and fluorine atoms contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine ligands, N-heterocyclic carbene (NHC) precursors, and other organocatalysts.
• Material Science: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings, allowing for the introduction of the 3-bromo-4-fluorobenzyl moiety into complex systems.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and process R&D for exploring new synthetic routes and creating compound libraries.

Basic Information

Product Name	3-Bromo-4-Fluorobenzyl Bromide
CAS No.	78239-71-1
Molecular Formula	C7H5Br2F
Molecular Weight	267.92 g/mol
Synonyms	1-(Bromomethyl)-3-bromo-4-fluorobenzene; 4-Fluoro-3-bromobenzyl Bromide; α,3-Dibromo-4-fluorotoluene; (3-Bromo-4-fluorophenyl)methyl Bromide; 3-Bromo-4-fluoro-benzylbromide; 3-Bromo-4-fluorobenzyl bromide; 78239-71-1; Benzene, 1-(bromomethyl)-3-bromo-4-fluoro-
EINECS	Contact for details

Quality Control

Every batch of our 3-Bromo-4-Fluorobenzyl Bromide is produced and tested under a strict quality management system. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques including HPLC, GC, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports your R&D and scale-up processes with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.