Description

Parathyroid Hormone (1-38), Human is a bioactive synthetic peptide fragment corresponding to the N-terminal region of the endogenous human parathyroid hormone. This compound is a critical research tool and pharmaceutical intermediate for studying calcium and phosphate metabolism, bone biology, and renal function. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical developers focused on metabolic disorders and osteoporosis therapeutics. The product is supplied as a high-purity lyophilized powder to ensure consistent biological activity and experimental reproducibility.

Application

• Biomedical Research: Fundamental studies on PTH receptor (PTH1R) activation, signaling pathways, and the hormone's role in calcium homeostasis.
• Drug Discovery & Development: Serving as a reference standard, pharmacological tool, or starting material in the development of anabolic bone therapies and PTH analogs.
• In Vitro Assays: Used in cell-based assays (e.g., cAMP response) to screen for PTH agonists/antagonists or to calibrate bioassay systems.
• Metabolic Disease Models: Administration in animal models to induce hypercalcemic states or study disorders related to parathyroid gland function.
• Peptide Chemistry Reference: Acts as a well-characterized standard in analytical method development for peptide purity and stability testing.
• Quality Control: Employed as a system suitability standard in the pharmaceutical QC of related peptide hormone products.

Basic Information

Product Name	Parathyroid Hormone (1-38), Human
CAS No.	78232-94-7
Molecular Formula	C₁₈₁H₂₉₁N₅₅O₅₁S₂
Molecular Weight	≈ 4307.8 g/mol
Synonyms	Human Parathyroid Hormone (1-38); hPTH (1-38); PTH (1-38); Parathyrin (1-38); Parathormone fragment 1-38; Teriparatide fragment; N-terminal PTH; PTH 1-38 amide (human); CAS 78232-94-7
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (1-38), Human is manufactured under controlled conditions and subjected to rigorous analytical testing to ensure identity, purity, and biological potency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for HPLC purity, peptide content, amino acid analysis, and mass spectrometry. We adhere to stringent quality management principles suitable for research and development applications. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere. Keep container dry.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Stimulates cAMP production in suitable cell lines (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.