Description

Dazoxiben is a selective and potent inhibitor of thromboxane A2 synthase, a key enzyme in the arachidonic acid pathway. This pharmacological action makes it a valuable research tool and a compound of significant interest in the development of therapeutic agents targeting platelet aggregation and vasoconstriction. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) investigating cardiovascular diseases, thrombosis, and related inflammatory pathways.

Application

• Pharmacological Research: A critical reference standard and active compound in studies of thromboxane synthase inhibition and its effects on platelet function.
• Cardiovascular Disease Models: Used in preclinical research to investigate pathways related to atherosclerosis, myocardial infarction, and stroke.
• Inflammation Studies: Employed to explore the role of thromboxane A2 in various inflammatory conditions and immune responses.
• Drug Discovery & Development: Serves as a lead compound or biochemical tool in the screening and development of novel antiplatelet and antithrombotic agents.
• Biochemical Assay Development: Used to validate and calibrate enzymatic assays targeting thromboxane A2 synthase activity.
• Academic & Institutional Research: Supports fundamental research in biochemistry, pharmacology, and vascular biology at universities and research institutes.

Basic Information

Product Name	Dazoxiben
CAS No.	78218-09-4
Molecular Formula	C13H12N2O3
Molecular Weight	244.25 g/mol
Synonyms	UK-37,248; UK-37248; 4-[(1H-Imidazol-1-yl)methyl]benzoic Acid; 4-(Imidazol-1-ylmethyl)benzoic Acid; Dazoxiben Hydrochloride (salt form); Benzeneacetic acid, α-imidazol-1-yl-4-methyl-; Thromboxane Synthetase Inhibitor UK-37,248
EINECS	Contact for details

Quality Control

Our Dazoxiben is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.