Description

Insulin, Asn(B12)- is a high-purity, chemically modified insulin variant, specifically engineered for advanced research and development applications. This compound is critical for studying insulin structure-function relationships, receptor binding mechanisms, and the development of novel therapeutic analogs. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on endocrinology and metabolic disease research.

Application

• Biochemical Research: Used as a reference standard and active component in studies of insulin signaling pathways, protein-protein interactions, and hormone metabolism.
• Pharmaceutical Development: Serves as a key intermediate or model compound in the R&D of new insulin analogs and next-generation diabetes therapies.
• Receptor Binding Assays: Essential for in vitro and cell-based assays to evaluate the affinity and kinetics of insulin receptor binding.
• Structural Biology Studies: Employed in X-ray crystallography, NMR spectroscopy, and other techniques to elucidate the three-dimensional structure and dynamics of insulin.
• Quality Control Reference: Acts as a certified reference material (CRM) for the analysis and validation of insulin-based pharmaceuticals.

Basic Information

Product Name	Insulin, Asn(B12)-
CAS No.	78212-36-9
Molecular Formula	C254H377N65O76S6
Molecular Weight	~5807.9 g/mol
Synonyms	Asn(B12)-Insulin; Insulin Asn(B12) derivative; [AsnB12]-Insulin; B12-Asn Insulin; Insulin variant AsnB12; Insulin (Asn at position B12); Porcine Insulin Asn(B12) analog
EINECS	Contact for details

Quality Control

Our Insulin, Asn(B12)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including purity assay by HPLC, peptide mapping, and identity confirmation, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.