Description

1-(2-Hydroxy-Ethoxymethyl)-5-Trifluoromethyl-1H-Pyrimidine-2,4-Dione CAS NO 78097-09-3 is a high-value pyrimidine derivative characterized by its trifluoromethyl and hydroxymethyl ether functional groups. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents, particularly antiviral and anticancer drugs, where its unique structure imparts desirable biological activity and metabolic stability. It is essential for research and development chemists, process scale-up teams, and manufacturers in the fine chemical and active pharmaceutical ingredient (API) sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog antiviral drugs.
• Antiviral Drug Research: Used in the R&D of compounds targeting viruses such as herpesviruses and other DNA viruses.
• Oncology Research: Serves as a precursor for the development of chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Employed in studies of enzyme inhibition and as a probe for understanding biochemical pathways.
• Fine Chemical Synthesis: Utilized in custom synthesis and the production of complex, fluorinated organic molecules for various applications.
• Process Chemistry: Applied in route scouting and optimization for the commercial-scale manufacturing of specialty chemicals.

Basic Information

Product Name	1-(2-Hydroxy-Ethoxymethyl)-5-Trifluoromethyl-1H-Pyrimidine-2,4-Dione
CAS No.	78097-09-3
Molecular Formula	C8H9F3N2O4
Molecular Weight	254.16 g/mol
Synonyms	5-Trifluoromethyl-1-(2-hydroxyethoxymethyl)uracil; 1-[(2-Hydroxyethoxy)methyl]-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione; 1-(2-Hydroxyethoxymethyl)-5-trifluoromethyluracil; CF3-DHBU; Trifluoromethylated Uracil Derivative; NSC 382487; 5-CF3-1-HEMU
EINECS	Contact for details

Quality Control

Our 1-(2-Hydroxy-Ethoxymethyl)-5-Trifluoromethyl-1H-Pyrimidine-2,4-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for critical pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.