Description

Thyrotropin-Releasing Hormone, Nval(2)- CAS NO 78058-02-3 is a synthetic analog of the endogenous thyrotropin-releasing hormone (TRH), a key hypothalamic peptide. This modified peptide is engineered for enhanced stability and specificity in research and development applications. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focusing on neuroendocrinology, peptide therapeutics, and assay development.

Application

• Neuroendocrine Research: A critical tool for studying the hypothalamic-pituitary-thyroid (HPT) axis, thyroid-stimulating hormone (TSH) release, and prolactin secretion.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the development of novel peptide-based therapeutics for thyroid disorders and neurological conditions.
• Diagnostic Assays: Used as a calibrator or control in immunoassays and radioimmunoassays (RIA) designed to measure TRH or related hormones.
• Biochemical Studies: Employed in receptor binding studies to investigate TRH receptor (TRHR) affinity, signaling pathways, and downstream effects.
• Stability & Metabolism Research: The Nval(2) modification makes it a valuable model for studying peptide stability, degradation pathways, and metabolic fate.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, Nval(2)- CAS NO 78058-02-3
CAS No.	78058-02-3
Molecular Formula	C16H22N6O4
Molecular Weight	362.38 g/mol
Synonyms	TRH, Nval(2)-; Pyroglutamyl-Nvalyl-prolinamide; (2S)-1-[(2S)-2-[(2S)-5-Oxo-2-pyrrolidinyl]formamido]-4-methylpentanoyl]pyrrolidine-2-carboxamide; N-[(2S)-5-Oxo-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidin-2-yl]-L-norvalinamide; L-Pyroglutamyl-L-norvalyl-L-prolinamide; Norvaline2-TRH; TRH Analog; TRH (1-3) Tripeptide Analog
EINECS	Contact for details

Quality Control

Every batch of Thyrotropin-Releasing Hormone, Nval(2)- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with exacting research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.