Description

(Nle8,18,Tyr34)-Pth (1-34) (Human) CAS NO 78041-34-6 is a synthetic analog of the N-terminal fragment of human parathyroid hormone, engineered with specific amino acid substitutions to enhance stability and biological activity. This high-purity peptide is critical for advanced research in bone metabolism, calcium homeostasis, and endocrine signaling pathways. It is an essential reagent for pharmaceutical R&D, particularly in the development of novel therapeutics for osteoporosis and metabolic bone diseases, serving academic institutions, biotech firms, and contract research organizations globally.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active ingredient in preclinical studies for novel anabolic bone therapies targeting osteoporosis and hypoparathyroidism.
• Biochemical Assay Development: Serves as a critical ligand and calibrator in receptor binding assays (e.g., PTH1R activation) and cell-based activity tests to study signal transduction.
• Endocrinology & Metabolic Studies: A key tool for investigating the physiological and pharmacological effects of PTH on calcium and phosphate regulation in in vitro and ex vivo models.
• Peptide Chemistry & Stability Studies: Employed as a model compound to study the structure-activity relationships (SAR) and stability profiles of modified peptide hormones.
• Quality Control & Analytical Standards: Utilized as a high-purity certified reference material (CRM) for the qualification and validation of analytical methods like HPLC and mass spectrometry in QC laboratories.

Basic Information

Product Name	(Nle8,18,Tyr34)-Pth (1-34) (Human)
CAS No.	78041-34-6
Molecular Formula	C181H291N55O51S2
Molecular Weight	4107.7 g/mol (approximate)
Synonyms	Parathyroid Hormone (1-34) human, [Nle8,18, Tyr34]-hPTH(1-34); hPTH(1-34) analog; PTH (1-34) amide, human; Teriparatide acetate analog; [Nle8,18,Tyr34]-bPTH(1-34) amide; PTH 1-34 (Human) (Nle8,18,Tyr34); Synthetic human parathyroid hormone fragment 1-34 analog
EINECS	Contact for details

Quality Control

Our (Nle8,18,Tyr34)-Pth (1-34) (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports your need for reliable and consistent bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Determined by cell-based assay (COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.