Description

8-Methoxymethyl-3-Isobutyl-1-Methylxanthine is a high-purity xanthine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a key scaffold for developing novel therapeutic agents targeting adenosine receptors and phosphodiesterase (PDE) enzymes. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of specialized bioactive molecules for cardiovascular, neurological, and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel adenosine receptor antagonists and phosphodiesterase (PDE) inhibitors.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies to investigate signal transduction pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to produce more complex, target-specific molecules for preclinical evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	8-Methoxymethyl-3-Isobutyl-1-Methylxanthine
CAS No.	78033-08-6
Molecular Formula	C12H18N4O3
Molecular Weight	266.30 g/mol
Synonyms	8-(Methoxymethyl)-3-isobutyl-1-methylxanthine; 3-Isobutyl-1-methyl-8-(methoxymethyl)xanthine; IBMX derivative; 8-Methoxymethyl-IBMX; 1-Methyl-3-isobutyl-8-(methoxymethyl)xanthine; PDE Inhibitor Intermediate; Xanthine Derivative 78033-08-6
EINECS	Contact for details

Quality Control

Our 8-Methoxymethyl-3-Isobutyl-1-Methylxanthine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.