Description

L-Histidine Mono(4-Methyl-2-Oxovalerate) is a high-purity, chemically defined derivative of the essential amino acid L-Histidine. This compound is valued for its role as a stable and bioavailable source of L-Histidine in advanced nutritional and pharmaceutical formulations. It is primarily utilized by manufacturers in the nutraceutical, clinical nutrition, and pharmaceutical industries seeking precise ingredient control for parenteral nutrition, specialized dietary supplements, and research applications.

Application

• Parenteral Nutrition Solutions: A critical component in total parenteral nutrition (TPN) formulations, providing a bioavailable source of the essential amino acid L-Histidine for patients unable to receive oral nutrition.
• Specialized Clinical Nutrition: Used in medical nutrition products designed for metabolic disorders, critical care, and post-surgical recovery where precise amino acid profiles are required.
• High-End Nutraceuticals: Incorporated into premium dietary supplements targeting muscle support, immune function, and overall wellness due to the physiological roles of L-Histidine.
• Pharmaceutical Intermediates: Serves as a key building block or intermediate in the synthesis of more complex peptides, active pharmaceutical ingredients (APIs), or diagnostic agents.
• Biochemical Research: Employed in cell culture media, enzyme studies, and metabolic pathway research as a defined source of L-Histidine.
• Veterinary Nutrition: Used in formulations for high-value animal feeds, veterinary injectables, and pet nutritional supplements.

Basic Information

Product Name	L-Histidine Mono(4-Methyl-2-Oxovalerate)
CAS No.	78000-40-5
Molecular Formula	C11H18N3O4
Molecular Weight	256.28 g/mol
Synonyms	L-Histidine α-Ketoisocaproate Monohydrate; Histidine KIC; L-Histidine Mono(4-Methyl-2-oxopentanoate); (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid compound with 4-methyl-2-oxopentanoic acid; Histidine α-Ketoisocaproic Acid Salt; H-KIC; Histidine Ketoisocaproate; L-Histidine Ketoleucine
EINECS	Contact for details

Quality Control

Our L-Histidine Mono(4-Methyl-2-Oxovalerate) is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets stringent specifications suitable for pharmaceutical and nutritional applications. Certificates of Analysis (COA) documenting purity, chiral purity, and compliance with relevant internal specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a low-humidity environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Optical Rotation	+8.0° to +12.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.