Description

L-Histidine Mono(3-Methyl-2-Oxobutyrate) CAS NO 78000-39-2 is a high-purity, chemically modified derivative of the essential amino acid L-Histidine, designed for enhanced stability and bioavailability. This compound is critical for applications requiring precise biochemical activity and consistent quality, serving as a key intermediate in advanced pharmaceutical synthesis and nutritional science. It is primarily utilized by manufacturers in the pharmaceutical, nutraceutical, and research sectors for developing specialized therapeutic and nutritional formulations.

Application

• Pharmaceutical Intermediates: A key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Nutraceutical & Dietary Supplements: Used in high-performance amino acid supplements and clinical nutrition products for its metabolic and physiological roles.
• Biochemical Research: Serves as a critical reagent in enzymology studies, metabolic pathway research, and cell culture media preparation.
• Cosmetic & Personal Care: Incorporated into advanced skincare formulations for its potential role in skin conditioning and antioxidant properties.
• Veterinary Pharmaceuticals: Employed in the development of specialized amino acid supplements and therapeutic feeds for animal health.
• Food Science & Fortification: Used in the research and development of functional foods and medical foods requiring targeted amino acid delivery.

Basic Information

Product Name	L-Histidine Mono(3-Methyl-2-Oxobutyrate)
CAS No.	78000-39-2
Molecular Formula	C11H18N3O5
Molecular Weight	272.28 g/mol
Synonyms	L-Histidine α-Ketoisocaproate Monohydrate; Histidine KIC; L-Histidine Mono(3-Methyl-2-oxobutanoate); (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid compound with 4-methyl-2-oxopentanoic acid (1:1); H-His-OH•KIC; L-Histidine HMB precursor; Amino Acid-Keto Acid Salt; L-Histidine α-Ketoisocaproic Acid Salt
EINECS	Contact for details

Quality Control

Our L-Histidine Mono(3-Methyl-2-Oxobutyrate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets high-grade specifications for pharmaceutical and nutritional use. Certificates of Analysis (COA) documenting full compliance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	+10.0° to +15.0° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.