Description

N1-Acetylspermine Trihydrochloride is a chemically modified derivative of the natural polyamine spermine, characterized by its high-purity trihydrochloride salt form. This compound is a critical biochemical tool and research chemical, valued for its role in studying polyamine metabolism, cellular signaling, and enzyme interactions. It is primarily sought after by researchers and developers in the life sciences, pharmaceutical R&D, and academic biochemistry sectors for use as a reference standard, enzyme substrate, or precursor in synthetic pathways.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to polyamine metabolism, such as with spermidine/spermine N1-acetyltransferase (SSAT).
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and analysis of novel therapeutic agents targeting polyamine pathways.
• Cell Biology Studies: Employed to investigate the role of acetylated polyamines in cellular processes like proliferation, differentiation, and apoptosis.
• Diagnostic Reagent Manufacturing: Utilized in the formulation of assay kits and reagents for the quantitative analysis of polyamines in biological samples.
• Academic Research: A fundamental tool for universities and research institutes conducting fundamental studies on polyamine function and regulation.
• Quality Control: Acts as a certified reference material (CRM) for the calibration and validation of analytical methods (e.g., HPLC, LC-MS) in QC laboratories.

Basic Information

Product Name	N1-Acetylspermine Trihydrochloride
CAS No.	77928-70-2
Molecular Formula	C12H30N4O • 3HCl
Molecular Weight	397.78 g/mol
Synonyms	N1-Acetylspermine 3HCl; Acetylspermine Trihydrochloride; N(1)-Acetylspermine Trihydrochloride; Spermine, N1-acetyl-, trihydrochloride; 1-Acetylspermine Trihydrochloride; N-Acetylspermine Trihydrochloride; N1-Acetyl-1,4,8,11-tetraazaundecane Trihydrochloride
EINECS	Contact for details

Quality Control

Our N1-Acetylspermine Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.