Description

(Leu8,D-Trp22,Tyr25)-Somatostatin 28 CAS NO 77909-99-0 is a synthetic, biologically active peptide analog of somatostatin-28, a key regulatory hormone. This modified sequence, featuring specific amino acid substitutions, is designed for enhanced stability and targeted receptor binding affinity in research applications. It is primarily utilized by pharmaceutical researchers and biochemists in the development of novel therapeutic agents and as a critical tool in metabolic and endocrine system studies.

Application

• Pharmaceutical Research & Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of somatostatin receptor-targeted therapies.
• Biochemical Research: Used as a specific ligand in receptor binding assays and signal transduction studies to investigate the role of somatostatin in physiological processes.
• Endocrinology Studies: A vital tool for studying the inhibition of growth hormone, insulin, and glucagon secretion in experimental models.
• Neuroscience Research: Employed in research on neuropeptide function and the modulation of neurotransmitter release.
• Academia & Institutional Labs: Used in university and research institute settings for fundamental peptide chemistry and hormone action research.
• Preclinical Development: Acts as a key compound in the evaluation of pharmacokinetics, metabolism, and efficacy in animal models for potential drug candidates.

Basic Information

Product Name	(Leu8,D-Trp22,Tyr25)-Somatostatin 28
CAS No.	77909-99-0
Molecular Formula	C149H220N42O43S2
Molecular Weight	~3350.7 g/mol
Synonyms	Somatostatin-28 (8-Leucine, 22-D-Tryptophan, 25-Tyrosine); [Leu8,D-Trp22,Tyr25]-Somatostatin-28; SRIF-28 analog; SMS 28 analog; Somatotropin release-inhibiting factor (8-Leu,22-D-Trp,25-Tyr); H2N-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Leu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (modified sequence); Cyclic somatostatin-28 analog
EINECS	Contact for details

Quality Control

Our (Leu8,D-Trp22,Tyr25)-Somatostatin 28 is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC/IC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.