Description

Bradykinin, Gly-Leu-Met-Lys CAS NO 77761-20-7 is a synthetic peptide fragment of the endogenous bradykinin sequence, serving as a critical research tool and potential precursor in pharmaceutical development. This compound is essential for studying the kallikrein-kinin system, inflammation pathways, and receptor-ligand interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on cardiovascular, inflammatory, and pain-related therapeutic discovery.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of bradykinin B1 and B2 receptor pharmacology, vascular permeability, and inflammatory response mechanisms.
• Pharmaceutical Development: Acts as a key intermediate or building block in the synthesis of novel peptide-based drugs targeting hypertension, angioedema, and chronic pain.
• Diagnostic Reagent Production: Employed in the formulation of enzyme immunoassays (EIAs) and radioimmunoassays (RIAs) for the quantitative detection of kinin-related biomarkers.
• Cell Biology & Signal Transduction: Applied in in vitro cell culture models to investigate intracellular signaling cascades, such as those involving nitric oxide (NO) and prostaglandin release.
• Academic & Institutional Research: Serves as a fundamental reagent for university laboratories and contract research organizations (CROs) conducting basic science in physiology and pharmacology.

Basic Information

Product Name	Bradykinin, Gly-Leu-Met-Lys
CAS No.	77761-20-7
Molecular Formula	C26H46N8O7S
Molecular Weight	614.8 g/mol
Synonyms	Bradykinin Fragment 1-4; Glycyl-leucyl-methionyl-lysine; H-Gly-Leu-Met-Lys-OH; Bradykinin (1-4); BK (1-4); GLMK; Tetrapeptide Gly-Leu-Met-Lys
EINECS	Contact for details

Quality Control

Our Bradykinin, Gly-Leu-Met-Lys is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide Certificates of Analysis (COA) with detailed specifications for traceability and compliance. Our quality commitment ensures the material meets the stringent requirements of research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccants are recommended. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.