Description

Pyrimido(5,4-D)Pyrimidine, 8-((Phenylmethyl)Thio)-2-(1-Piperazinyl)-4- (4-Thiomorpholinyl)-, S-Oxide is a sophisticated heterocyclic compound featuring a complex polycyclic core functionalized with piperazine and thiomorpholine moieties. This molecular architecture makes it a valuable advanced pharmaceutical intermediate and a key scaffold for medicinal chemistry research, particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by R&D scientists and process chemists in pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Kinase Inhibitor Research: Used as a core scaffold for the design and synthesis of potential kinase inhibitors due to its pyrimidopyrimidine structure.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties of lead compounds.
• Biochemical Tool Compound: May be utilized as a reference standard or probe in biochemical assays to study cellular signaling mechanisms.
• Fine Chemical Synthesis: Acts as a specialized intermediate in multi-step organic syntheses for producing high-value, complex molecules.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and development services for the life sciences industry.

Basic Information

Product Name	Pyrimido(5,4-D)Pyrimidine, 8-((Phenylmethyl)Thio)-2-(1-Piperazinyl)-4- (4-Thiomorpholinyl)-, S-Oxide
CAS No.	77749-76-9
Molecular Formula	C21H28N6OS2
Molecular Weight	444.62 g/mol
Synonyms	8-(Benzylthio)-2-(piperazin-1-yl)-4-(thiomorpholin-4-yl)pyrimido[5,4-d]pyrimidine 1-oxide; 2-(1-Piperazinyl)-8-[(phenylmethyl)thio]-4-(4-thiomorpholinyl)pyrimido[5,4-d]pyrimidine S-oxide; 8-(Benzylsulfanyl)-2-piperazin-1-yl-4-thiomorpholin-4-yl-pyrimido[5,4-d]pyrimidine 1-oxide; Pyrimido[5,4-d]pyrimidine, 8-[(phenylmethyl)thio]-2-(1-piperazinyl)-4-(4-thiomorpholinyl)-, 1-oxide; CAS 77749-76-9
EINECS	Contact for details

Quality Control

Our production of Pyrimido(5,4-D)Pyrimidine, 8-((Phenylmethyl)Thio)-2-(1-Piperazinyl)-4- (4-Thiomorpholinyl)-, S-Oxide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure consistency and meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.