Description

β-Neoendorphin is a potent endogenous opioid peptide derived from the precursor protein proenkephalin B. This compound is of significant interest for its role as a selective agonist for the κ-opioid receptor, making it a crucial tool for neurobiological and pharmacological research. It is primarily utilized by research institutions and pharmaceutical companies investigating pain mechanisms, neuropsychiatric disorders, and the development of novel analgesic therapeutics.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of opioid receptor signaling, neurotransmitter release, and neuronal excitability.
• Pharmacological Studies: Serves as a key ligand in receptor binding assays, functional activity tests (e.g., GTPγS binding), and selectivity profiling for κ-opioid receptors.
• Pain Research: Employed in preclinical models to study the endogenous opioid system's role in nociception, analgesia, and the development of tolerance.
• Biochemical Assay Development: Acts as a critical component in the development and validation of ELISA, RIA, or other immunoassay kits targeting opioid peptides.
• Drug Discovery: Provides a structural template for the design and synthesis of novel peptide-based analgesics with potentially improved efficacy and reduced side-effect profiles.
• Academic & Clinical Research: Supports fundamental research into stress response, mood regulation, addiction, and other behaviors modulated by the κ-opioid system.

Basic Information

Product Name	β-Neoendorphin
CAS No.	77739-21-0
Molecular Formula	C₆₀H₈₈N₁₄O₁₅
Molecular Weight	1261.4 g/mol
Synonyms	β-Neoendorphin; Neoendorphin, β-; β-Neo-Endorphin; Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys (Porcine); Dynorphin B (1-9); Leumorphin (1-9); Porcine β-Neoendorphin; Rimorphin
EINECS	Contact for details

Quality Control

Our β-Neoendorphin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and mass confirmation. A Certificate of Analysis (COA) detailing identity, purity, and content is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.