Description

Enoximone CAS NO 77671-31-9 is a selective phosphodiesterase III (PDE III) inhibitor, a high-purity active pharmaceutical ingredient (API) of significant pharmacological interest. Its primary value lies in its potent inotropic and vasodilatory effects, making it a critical compound for cardiovascular research and development. This product is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on developing and studying treatments for acute and chronic heart failure.

Application

• Pharmaceutical API: Core active ingredient in the formulation of cardiovascular drugs, specifically for short-term intravenous treatment of congestive heart failure.
• Cardiovascular Research: A key reference standard and tool compound for investigating myocardial contractility, vascular tone, and PDE III enzyme inhibition mechanisms.
• Preclinical & Clinical Studies: Used in the development and validation of new therapeutic agents targeting heart failure and related hemodynamic disorders.
• Analytical Reference Standard: Serves as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quality control and pharmacokinetic studies.
• Biochemical Assay Development: Employed in enzymatic assays to screen for and evaluate new PDE III inhibitors.

Basic Information

Product Name	Enoximone
CAS No.	77671-31-9
Molecular Formula	C12H12N2O2
Molecular Weight	216.24 g/mol
Synonyms	1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one; Enoximone; Fenoximone; MDL 17,043; Perfan; 4-Methyl-5-[4-(methylsulfanyl)benzoyl]-1,3-dihydroimidazol-2-one; MDL-17043
EINECS	Contact for details

Quality Control

Our Enoximone is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.