Description

Dermorphin, 4-Hyp(6)- CAS NO 77614-17-6 is a synthetic peptide analog of the potent opioid heptapeptide dermorphin, specifically modified with a hydroxyproline residue at position 6. This modification is designed to enhance metabolic stability and influence receptor binding affinity, making it a critical tool for advanced pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers investigating novel analgesic pathways and peptide-based therapeutics. The compound's specific structure allows for the study of opioid receptor interactions and the development of peptides with improved pharmacokinetic profiles.

Application

• Neuroscience Research: Used as a reference standard and active compound in studies of mu-opioid receptor (MOR) signaling, analgesia, and addiction mechanisms.
• Analgesic Drug Discovery: Serves as a lead compound or structural template for developing new, potent peptide-based pain relievers with potentially reduced side-effect profiles.
• Biochemical Assays: Employed in competitive binding assays, receptor activation studies, and in vitro pharmacological profiling to characterize compound activity.
• Metabolic Stability Studies: The 4-Hyp modification makes it a model compound for investigating the impact of proline hydroxylation on peptide degradation and bioavailability.
• Academic & Institutional Research: Fundamental research tool in university and government labs focusing on neuropeptides, opioid systems, and peptide engineering.

Basic Information

Product Name	Dermorphin, 4-Hyp(6)-
CAS No.	77614-17-6
Molecular Formula	C₄₀H₅₆N₁₀O₁₁
Molecular Weight	861.0 g/mol
Synonyms	[Hyp6]-Dermorphin; 4-Hydroxyproline6-Dermorphin; Dermorphin (4-Hyp(6)-); H-Tyr-D-Ala-Phe-Gly-Tyr-Hyp-Ser-NH₂; Tyr-D-Ala-Phe-Gly-Tyr-Hyp-Ser-NH₂; Opioid peptide analog; [4-Hyp6]-Dermorphin; Dermorphin, 4-hydroxyproline(6)-
EINECS	Contact for details

Quality Control

Our Dermorphin, 4-Hyp(6)- is manufactured for research use under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by Mass Spectrometry (MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research requirements. For specific purity grades or custom quality specifications, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.