Description

Cholecystokinin (25-33), Thr(28)-Nle(31)- is a synthetic peptide fragment of the gastrointestinal hormone cholecystokinin (CCK). This specific analog, with the substitution of norleucine at position 31, is valued for its enhanced stability and biological activity in research applications. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neurogastroenterology, appetite regulation, and peptide-based drug discovery.

Application

• Pharmacological Research: Used as a potent and selective agonist for studying CCK receptor subtypes (CCKA and CCKB) in vitro and in vivo.
• Neuroscience Studies: Investigates the role of CCK in anxiety, satiety signaling, pain perception, and dopaminergic pathways.
• Gastrointestinal Physiology: A key tool for exploring CCK's effects on pancreatic enzyme secretion, gallbladder contraction, and gut motility.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel therapeutics for metabolic and CNS disorders.
• Biochemical Assays: Employed in receptor binding assays, functional cell-based assays, and signal transduction studies to validate drug candidates.

Basic Information

Product Name	Cholecystokinin (25-33), Thr(28)-Nle(31)-
CAS No.	77568-41-3
Molecular Formula	C52H78N12O14S
Molecular Weight	1103.3 g/mol
Synonyms	CCK (25-33), Thr28-Nle31-; CCK-9, Nle31-; Sincalide analog; Cholecystokinin nonapeptide, Nle31-; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (Nle31 variant); H-Asp-Tyr(SO3H)-Met-Gly-Trp-Nle-Asp-Phe-NH2; CCK-8 (Nle31); [Nle31]-CCK (25-33)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Cholecystokinin (25-33), Thr(28)-Nle(31)- undergoes comprehensive testing to ensure identity, purity, and biological activity, meeting the stringent requirements of research and development. Certificates of Analysis (COA) detailing results for purity (HPLC), amino acid analysis, mass spectrometry (MS), and other relevant tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.