Description

2-Cyano-4-Fluorobenzaldehyde is a versatile aromatic aldehyde building block characterized by its cyano and fluorine substituents, which impart unique electronic and steric properties. This compound is essential for facilitating complex organic syntheses, particularly in the development of high-value, functionalized molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for constructing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as dyes and semiconductors, where its electron-withdrawing groups are beneficial.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Scale-Up: Available for contract manufacturing and custom synthesis projects from gram to multi-kilogram scale.

Basic Information

Product Name	2-Cyano-4-Fluorobenzaldehyde
CAS No.	77532-90-2
Molecular Formula	C8H4FNO
Molecular Weight	149.12 g/mol
Synonyms	4-Fluoro-2-formylbenzonitrile; 4-Fluoro-2-cyanobenzaldehyde; 2-Formyl-5-fluorobenzonitrile; 5-Fluoro-2-cyanobenzaldehyde; Benzonitrile, 4-fluoro-2-formyl-; 2-Cyano-4-fluorobenzaldehyde; 4-Fluorophthalaldehyde nitrile; 77532-90-2
EINECS	Contact for details

Quality Control

Our 2-Cyano-4-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening sealed containers. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.