Description

n-Methyl-D-Glutamic Acid is a non-proteinogenic amino acid derivative of D-glutamic acid, featuring a methyl group substitution on the nitrogen atom. This specific stereochemistry and modification make it a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and industrial R&D departments focused on peptide chemistry, neuroscience, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of peptide-based drugs, enzyme inhibitors, and neuroactive compounds.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving glutamate receptors or metabolic pathways.
• Peptide Synthesis: Employed as a modified amino acid residue to introduce specific structural or functional properties into synthetic peptides.
• Neuroscience Studies: Applied in research related to glutamate neurotransmission, receptor binding assays, and metabolic tracing.
• Asymmetric Synthesis: Acts as a chiral pool starting material or auxiliary for the synthesis of complex molecules requiring high enantiomeric purity.
• Reference Standard: Used as a high-purity analytical standard in chromatography (HPLC, GC) for method development and quality control in related chemical production.

Basic Information

Product Name	n-Methyl-D-Glutamic Acid
CAS No.	77481-28-8
Molecular Formula	C6H11NO4
Molecular Weight	161.16 g/mol
Synonyms	(2R)-2-(Methylamino)pentanedioic acid; D-α-Methylaminoglutaric acid; N-Methyl-D-glutamate; (R)-2-(Methylamino)glutaric acid; D-N-Methylglutamic acid; NMGA; MDGA
EINECS	Contact for details

Quality Control

Our n-Methyl-D-Glutamic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from methods including HPLC, chiral analysis, and NMR. Specifications are designed to meet the rigorous demands of pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.