Description

Fmoc-Nle-Oh CAS NO 77284-32-3 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient assembly of complex peptide sequences for research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on peptide-based drug discovery and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Acts as a reagent for introducing the norleucine residue into proteins or other biomolecules for labeling or structural modification.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Biochemical Research: Utilized in studies of protein structure-function relationships, enzyme substrates, and receptor ligands.
• Process Development: Serves as a key raw material in scaling up peptide manufacturing processes under GMP conditions.

Basic Information

Product Name	Fmoc-Nle-Oh
CAS No.	77284-32-3
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-Norleucine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)hexanoic acid; Fmoc-L-Nle-OH; Fmoc-L-2-Aminohexanoic Acid; N-α-Fmoc-L-norleucine; N-Fmoc-L-norleucine; Fmoc-Nle
EINECS	Contact for details

Quality Control

Our Fmoc-Nle-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks, including ICH guidelines, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.