Description

(D-Pro2,D-Phe7,D-Trp9)-Substance P is a synthetic, biologically active peptide analog of the neuropeptide Substance P, designed with specific D-amino acid substitutions to enhance its metabolic stability and receptor selectivity. This compound is a potent and selective antagonist of the neurokinin-1 (NK1) receptor, making it a critical research tool for studying neurogenic inflammation, pain transmission, and central nervous system disorders. It is primarily utilized by pharmaceutical researchers, neuroscientists, and contract research organizations (CROs) engaged in preclinical drug discovery and neuropharmacology studies.

Application

• Neuroscience Research: As a selective NK1 receptor antagonist for investigating the role of Substance P in pain pathways, migraine, anxiety, and depression.
• Pharmacological Studies: Used in in vitro and in vivo assays to characterize receptor binding, signal transduction, and the physiological effects of NK1 receptor blockade.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel therapeutics targeting neurokinin receptors.
• Inflammation Research: Employed to study neurogenic inflammation and the interaction between the nervous and immune systems.
• Academic & Institutional Research: A key reagent for university labs and research institutes focusing on peptide chemistry, neuropeptides, and receptor biology.

Basic Information

Product Name	(D-Pro2,D-Phe7,D-Trp9)-Substance P
CAS No.	77275-70-8
Molecular Formula	C63H83N13O13S
Molecular Weight	1262.5 g/mol
Synonyms	[D-Pro2, D-Phe7, D-Trp9]-Substance P; (D-Pro2, D-Phe7, D-Trp9)-SP; Substance P (2-11), [D-Pro2, D-Phe7, D-Trp9]-; Neurokinin 1 Receptor Antagonist; NK1 Antagonist; SP Antagonist; Arg-Pro-Lys-Pro-D-Pro-Gln-D-Phe-D-Trp-Nle-NH2; [D-Trp7,9, Nle11]-Substance P (4-11)
EINECS	Contact for details

Quality Control

Our (D-Pro2,D-Phe7,D-Trp9)-Substance P is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines suitable for research-grade bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Peptide Content	≥80%
Solubility	Soluble in DMSO, acetic acid; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.