Description

β-Endorphin D-Argo is a synthetic peptide analog of the endogenous opioid neuropeptide β-endorphin, where the arginine residue is in the D-configuration. This modification enhances its metabolic stability and receptor selectivity, making it a critical research tool for studying opioid receptor pathways and pain modulation mechanisms. It is essential for pharmaceutical R&D, academic neuroscience research, and the development of novel therapeutic agents targeting the central nervous system.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to investigate the role of opioid receptors in pain, stress, and reward pathways.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the design and screening of new analgesic and neuroprotective agents.
• Biochemical Analysis: Employed in enzymatic stability studies and as a substrate to characterize peptidase activity due to its modified structure.
• In Vitro & Ex Vivo Studies: Applied in cell-based assays and tissue bath experiments to study signal transduction and physiological responses mediated by opioid receptors.
• Analytical Standard: Used for method development, calibration, and quality control in HPLC, LC-MS, and other chromatographic systems for peptide analysis.

Basic Information

Product Name	β-Endorphin D-Argo
CAS No.	77271-25-1
Molecular Formula	C158H251N47O46S
Molecular Weight	3466.0 g/mol
Synonyms	β-Endorphin (Arg0, D-Arg24); D-Arg24-β-Endorphin; β-Endorphin, D-Arg24 analog; [D-Arg24]-β-Endorphin; Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-D-Arg-Asn-Ala-Tyr-Lys-Lys-Gly-Glu; Opioid peptide analog
EINECS	Contact for details

Quality Control

Our β-Endorphin D-Argo is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.