Description

2-Methyl-4-(Trifluoromethyl)Phenol is a versatile fluorinated phenolic compound characterized by its trifluoromethyl and methyl substituents on the aromatic ring. This structural motif imparts unique physicochemical properties, making it a valuable advanced intermediate for the synthesis of complex molecules. It is primarily sought after by pharmaceutical, agrochemical, and specialty chemical manufacturers for research and development as well as production-scale applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group is a critical pharmacophore for activity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in display technologies due to its ability to modify polarity and intermolecular interactions.
• Polymer Additives: Acts as a monomer or stabilizer in high-performance polymers, contributing to thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a protecting group or directing agent in complex organic transformations.
• Dyestuff and Pigment Intermediate: Utilized in the manufacture of specialized dyes and pigments where fluorine substitution alters color fastness and solubility.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethyl)Phenol
CAS No.	77227-90-8
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	4-Hydroxy-3-methylbenzotrifluoride; 3-Methyl-4-hydroxybenzotrifluoride; 2-Methyl-4-(trifluoromethyl)phenol; 4-(Trifluoromethyl)-2-methylphenol; o-Cresol, 4-(trifluoromethyl)-; 2-Methyl-α,α,α-trifluoro-p-cresol; 4-Trifluoromethyl-2-methylphenol; 2-Methyl-4-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-4-(Trifluoromethyl)Phenol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical specifications. Our quality system is designed to support cGMP and ISO standards for traceability and reliability, meeting the rigorous demands of global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.