Description

2-Fluoro-4-(Trifluoromethyl)Phenol is a versatile fluorinated phenolic compound that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, imparts valuable properties such as enhanced lipophilicity, metabolic stability, and electronic effects to target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for improved bioavailability and target binding.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to efficacy and environmental persistence profiles.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies, leveraging its polarizability and stability.
• Polymer Chemistry: Acts as a monomer or modifier in the creation of specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, etherifications, and as a protecting group precursor in complex multi-step synthetic routes.
• Material Science Research: Utilized in the development of novel organic electronic materials, dyes, and pigments due to its electron-withdrawing characteristics.

Basic Information

Product Name	2-Fluoro-4-(Trifluoromethyl)Phenol
CAS No.	77227-78-2
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-p-cresol; 4-Hydroxy-3-fluorobenzotrifluoride; 3-Fluoro-4-hydroxybenzotrifluoride; 2-Fluoro-4-(trifluoromethyl)phenol; Phenol, 2-fluoro-4-(trifluoromethyl)-; 2-Fluoro-α,α,α-trifluoro-4-cresol; 2-Fluoro-4-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for demanding synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.