Description

Oxytocin, Sar(7)- CAS NO 77225-24-2 is a synthetic peptide analog of the neurohypophysial hormone oxytocin, specifically modified at the seventh position with sarcosine (Sar). This structural modification is designed to enhance metabolic stability and receptor selectivity, making it a critical tool for advanced biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers investigating neuroendocrine pathways, peptide therapeutics, and receptor-ligand interactions.

Application

• Biomedical Research: Used as a selective agonist/antagonist in studies of oxytocin and vasopressin receptor subtypes to understand social behavior, stress response, and reproductive physiology.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the design of novel peptide-based therapeutics targeting central nervous system disorders.
• Pharmacological Assays: Employed in in vitro and in vivo models to characterize receptor binding affinity, functional activity, and signal transduction mechanisms.
• Biochemical Studies: Utilized to investigate the structure-activity relationships (SAR) of neurohypophysial hormones and the impact of amino acid substitutions on peptide stability and potency.
• Academic & Clinical Research: Supports fundamental research into the role of oxytocin in autism spectrum disorders, anxiety, depression, and maternal bonding.

Basic Information

Product Name	Oxytocin, Sar(7)-
CAS No.	77225-24-2
Molecular Formula	C₄₅H₆₇N₁₁O₁₂S₂
Molecular Weight	1006.2 g/mol
Synonyms	[Sar⁷]-Oxytocin; 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-13-(2-amino-2-oxoethyl)-7-(carbamoylmethyl)-16-(4-hydroxybenzyl)-10-(1H-imidazol-5-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicos-4-yl]carbonyl}-L-prolyl-L-leucylglycinamide; Sar⁷-Oxytocin; Oxytocin (7-sarcosine); Desamino-1-carba-2-O-methyltyrosine-4-threonine-8-ornithine-oxytocin (sarcosine-7 analog)
EINECS	Contact for details

Quality Control

Our Oxytocin, Sar(7)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and residual solvents are provided to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.