Description

Enkephalinamide, Thr(2)-Delta(3)Pro(5)- CAS NO 77217-02-8 is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically engineered with modifications at the second and fifth positions. This compound is of significant interest for its potential role in neurobiological research and pharmaceutical development, particularly in the study of opioid receptor interactions and pain modulation pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, analgesic discovery, and peptide-based therapeutics.

Application

• Neuroscience Research: Used as a tool compound to study the binding affinity, selectivity, and functional activity of delta and mu opioid receptors in vitro and in vivo.
• Analgesic Drug Discovery: Serves as a key intermediate or reference standard in the development of novel, non-addictive pain management therapies.
• Biochemical Assays: Employed in competitive binding assays, receptor activation studies, and signal transduction pathway analysis.
• Peptide Chemistry & Pharmacology: Acts as a model substrate for investigating structure-activity relationships (SAR) of modified enkephalin analogs.
• Reference Standard: Provides a high-purity benchmark for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	Enkephalinamide, Thr(2)-Delta(3)Pro(5)-
CAS No.	77217-02-8
Molecular Formula	C28H41N7O7
Molecular Weight	587.67 g/mol
Synonyms	[Thr², δ³-Pro⁵]-Enkephalinamide; H-Tyr-D-Thr-Gly-Phe-δ³-Pro-NH₂; Delta(3)Pro(5)-Enkephalinamide; (2-D-Threonine, 5-(3-dehydroproline))-enkephalinamide; Modified Enkephalin Peptide; Opioid Receptor Ligand; D-Thr², δ³-Pro⁵ Enkephalin Amide
EINECS	Contact for details

Quality Control

Our Enkephalinamide, Thr(2)-Delta(3)Pro(5)- is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and MS for identity confirmation, to ensure consistent quality and batch-to-batch reproducibility. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.