Description

5-Fluoro-1-(2'', 3'', 5''-Tri-o-Benzoyl-β-L-Ribofuranosyl)Uracil is a sophisticated nucleoside analogue derivative, serving as a critical protected intermediate in the synthesis of biologically active compounds. Its primary value lies in enabling precise chemical modifications for the development of novel antiviral and anticancer agents. This high-purity building block is essential for pharmaceutical R&D laboratories and fine chemical manufacturers focused on nucleoside-based drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key protected precursor in the multi-step synthesis of fluorinated nucleoside analogues for antiviral and anticancer research.
• Antiviral Drug Development: Used in the research and production of experimental therapeutics targeting viral polymerases.
• Oncology Research: Serves as a building block for creating potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in studies investigating enzyme mechanisms, particularly those involving nucleoside-processing enzymes.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for complex nucleoside drugs under GMP-like conditions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke molecules for client projects.

Basic Information

Product Name	5-Fluoro-1-(2'', 3'', 5''-Tri-o-Benzoyl-β-L-Ribofuranosyl)Uracil
CAS No.	77180-90-6
Molecular Formula	C30H23FN2O9
Molecular Weight	574.51 g/mol
Synonyms	1-(2,3,5-Tri-O-benzoyl-β-L-ribofuranosyl)-5-fluorouracil; 5-Fluoro-1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)uracil; 5-Fluoro-1-(2,3,5-tri-O-benzoyl-β-L-ribosyl)uracil; 2',3',5'-Tri-O-benzoyl-5-fluoro-β-L-uridine; 5-Fluoro-2',3',5'-tri-O-benzoyl-β-L-uridine; Protected 5-Fluoro-L-uridine; L-FUrd(Bz)3; 5-FLU(Bz)3
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-(2'', 3'', 5''-Tri-o-Benzoyl-β-L-Ribofuranosyl)Uracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.