Description

L-Leu-Leu-Obzl-Hcl CAS NO 77167-53-4 is a protected dipeptide derivative, specifically the benzyl ester hydrochloride salt of the L-leucyl-L-leucine dipeptide. This compound serves as a crucial building block and intermediate in advanced organic synthesis, particularly for the construction of complex peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics research, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the solid-phase and solution-phase synthesis of therapeutic peptides and peptide-based drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and proteomics research to investigate leucine-specific processes.
• Organic Synthesis: Serves as a protected dipeptide unit for constructing longer peptide chains or more complex molecular architectures in medicinal chemistry.
• Peptidomimetic Development: Acts as a starting material for creating non-natural peptide analogs with enhanced stability or biological activity.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-Leu-Leu-Obzl-Hcl
CAS No.	77167-53-4
Molecular Formula	C20H31N3O4 • HCl
Molecular Weight	414.94 g/mol (free base: 377.48 g/mol)
Synonyms	L-Leucyl-L-leucine benzyl ester hydrochloride; Benzyl L-leucyl-L-leucinate hydrochloride; H-Leu-Leu-OBzl • HCl; Leu-Leu-OBzl hydrochloride; N-(N-L-Leucyl-L-leucyl)benzyl ester hydrochloride; (S)-Benzyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrochloride; L-Leu-L-Leu-OBzl HCl
EINECS	Contact for details

Quality Control

Our L-Leu-Leu-Obzl-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets stringent specifications for research and synthesis applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.