Description

Substance P (6-11), Pglu(6)-n-Meleu(10)- is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 6 through 11 with pyroglutamic acid and norleucine modifications. This compound is a critical research tool for investigating the structure-activity relationships of Substance P, particularly its interaction with neurokinin-1 (NK-1) receptors. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptides for biochemical assays, receptor binding studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Used as a selective ligand in studies of the NK-1 receptor pathway, pain signaling, and neuroinflammation.
• Pharmacological Assays: Serves as a reference standard or active agent in in vitro and in vivo bioassays to evaluate substance P antagonists and agonists.
• Drug Discovery & Development: A key intermediate or tool compound for designing and screening new peptide-based therapeutics targeting neurological disorders.
• Biochemical Studies: Employed in enzymatic degradation studies and metabolic pathway analysis related to neuropeptides.
• Academic & Institutional Research: Fundamental reagent for university and research institute labs focusing on neurochemistry and peptide biology.

Basic Information

Product Name	Substance P (6-11), Pglu(6)-n-Meleu(10)-
CAS No.	77160-86-2
Molecular Formula	C39H62N10O9S
Molecular Weight	846.0 g/mol
Synonyms	Substance P (6-11) amide; [pGlu6, Nle10]-Substance P (6-11); [pGlu6, Norleucine10]-Substance P (6-11); Arg-Pro-Lys-Pro-pGlu-Phe-Nle-NH2; SP (6-11); Neurokinin P (6-11) fragment; NK-1 receptor ligand fragment
EINECS	Contact for details

Quality Control

Our Substance P (6-11), Pglu(6)-n-Meleu(10)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.