Description

Substance P (6-11), Pglu(6)-n-Mephe(7)- CAS NO 77160-85-1 is a specific bioactive fragment of the neuropeptide Substance P, designed for targeted research applications. This synthetic peptide is crucial for studying the structure-activity relationships of Substance P, particularly its interaction with neurokinin receptors. It is an essential tool for researchers in neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptides for receptor binding assays, signal transduction studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Used as a selective ligand to study the physiological and pathological roles of Substance P fragments in the central and peripheral nervous systems.
• Pharmacological Assays: Critical for receptor binding studies and functional assays targeting Neurokinin 1 (NK1) receptors to evaluate agonist/antagonist activity.
• Drug Discovery & Development: Serves as a key reference standard and intermediate in the design and screening of new analgesic, anti-inflammatory, or neuroprotective compounds.
• Biochemical Research: Employed in enzymatic degradation studies and metabolic pathway analysis to understand peptide stability and turnover.
• Academic & Institutional Research: A fundamental reagent for university and institutional labs conducting basic research on neuropeptides and peptidergic signaling.

Basic Information

Product Name	Substance P (6-11), Pglu(6)-n-Mephe(7)- CAS NO 77160-85-1
CAS No.	77160-85-1
Molecular Formula	C38H53N9O8S
Molecular Weight	795.95 g/mol
Synonyms	Substance P Fragment 6-11; [pGlu6, N-Me-Phe8]-Substance P (6-11); Pyr-Gln-Phe-Phe-N-Me-Phe-Leu-Met-NH2; H-pGlu-Gln-Phe-Phe-N-Me-Phe-Leu-Met-NH2; Neurokinin P (6-11) fragment, modified; NK1 receptor ligand fragment; SP (6-11) analog
EINECS	Contact for details

Quality Control

Our Substance P (6-11) fragment is manufactured under strict quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, peptide content, and solvent residues. Our quality system is designed to meet the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.