Description

(S)-2-Amino-3-(Benzo[D][1,3]Dioxol-5-Yl)Propanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative, specifically the hydrochloride salt of L-DOPA methyl ester's precursor. This compound is a critical chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs) for neurological and cardiovascular applications, as well as for creating novel peptide-based therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of L-DOPA (Levodopa) analogs and other catecholamine-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used as a precursor in studies related to Parkinson's disease, dopamine metabolism, and neurotransmitter pathways.
• Peptide Synthesis: Serves as a protected amino acid derivative for the solid-phase and solution-phase synthesis of bioactive peptides and peptidomimetics.
• Asymmetric Catalysis: Employed as a chiral auxiliary or ligand in asymmetric synthesis to induce stereoselectivity in chemical reactions.
• Biochemical Standard: Utilized as a reference standard in analytical methods (HPLC, LC-MS) for quality control and metabolic studies.
• Chemical Biology Probes: Acts as a building block for developing molecular probes to study enzyme mechanisms and protein interactions.

Basic Information

Product Name	(S)-2-Amino-3-(Benzo[D][1,3]Dioxol-5-Yl)Propanoic Acid Hydrochloride
CAS No.	77141-01-6
Molecular Formula	C10H12ClNO4
Molecular Weight	245.66 g/mol
Synonyms	L-3,4-Methylenedioxyphenylalanine hydrochloride; (S)-2-Amino-3-(1,3-benzodioxol-5-yl)propanoic acid hydrochloride; L-MDOPA hydrochloride; (S)-α-Amino-1,3-benzodioxole-5-propanoic acid hydrochloride; 3,4-(Methylenedioxy)-L-phenylalanine HCl; (S)-3-(Benzo[d][1,3]dioxol-5-yl)-2-aminopropanoic acid hydrochloride; (S)-2-Amino-3-(3,4-methylenedioxyphenyl)propionic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(Benzo[D][1,3]Dioxol-5-Yl)Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.