Description

Fmoc-Tyr(Me)-Oh CAS NO 77128-72-4 is a protected tyrosine derivative, specifically featuring an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine and a methyl ether on the phenolic hydroxyl. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require high-purity, sequence-specific amino acid derivatives.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental monomer for the Fmoc-strategy synthesis of therapeutic peptides and peptide hormones.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Probe Development: Serves as a modified tyrosine residue for creating labeled peptides for diagnostic assays and imaging.
• Chemical Biology Research: Employed in studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Combinatorial Library Synthesis: A key component for generating diverse peptide libraries for drug discovery and screening.
• Material Science: Used in the synthesis of peptide-polymer hybrids and bio-inspired materials.

Basic Information

Product Name	Fmoc-Tyr(Me)-Oh
CAS No.	77128-72-4
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-O-methyl-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine; Fmoc-Tyr(OMe)-OH; (2S)-3-(4-Methoxyphenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid; Fmoc-L-Tyr(Me)-OH; N-Fmoc-O-methyl-L-tyrosine; Fmoc-O-methyltyrosine; Fmoc-Tyr(4-Me)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Me)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting or exceeding 98.5% (HPLC) specification. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant GMP guidelines for pharmaceutical intermediates, and our quality systems support regulatory filings for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.